Medical School

Postgraduate research profiles


Matthew Albrecht

Start date

Mar 2007

Submission date

Matthew Albrecht


The effects of dopamine manipulation in healthy subjects on schizophrenia endophenotypes


Dopamine antagonists are the predominant treatment of schizophrenia and psychosis and dopamine agonists can cause psychotic symptoms with paranoid features in people without a prior history of psychosis. I am investigating how pharmacological manipulation of dopamine in healthy subjects affects several endophenotypes found to be affected in people with schizophrenia. These are- P300, PPI, 40 Hz ASSR and gamma synchrony.

Why my research is important

Investigating how dopamine affects several endophenotypes of schizophrenia will help us to better understand the role of dopamine in psychosis.