Medical School

Postgraduate research profiles

Contact

Louis Ma

Phone: (+61 8) 9224 0245


Start date

Jan 2015

Submission date

Jan 2019

Louis Ma

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Thesis

Lipoprotein(a) Metabolism in Subjects at High Risk of Cardiovascular Disease

Summary

Lipoprotein(a) [Lp(a)] have similar structures to low-density lipoprotein (LDL), with an apolipoprotein B (apoB) that is covalently bounded to apolipoprotein(a) [apo(a)]. Elevated plasma concentration of Lp(a) may be associated with cardiovascular disease (CVD). The physiology and metabolism of Lp(a) is unclear. Thus, understanding the metabolism of Lp(a) and its protein components is significant in a scientific and a clinical matter.

Why my research is important

CVD is the leading cause of death in Australia. In 2007, 34% of all registered deaths were associated with CVD and it is estimated that 3.5 million Australians have chronic CVD conditions. To effectively treat and prevent CVD, it is significant to understand the mechanisms, pathways and factors that regulate lipid and lipoprotein metabolism. Such knowledge will clarify the pathophysiology of dyslipidemia and to design more effective modes of treatment to lower CVD risk.