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Anahita Hamidi


Start date

Nov 2013

Submission date

Nov 2016

Anahita Hamidi

Thesis

Evaluation of cardio-metabolic risk factors in adolescents and young adults: impact on cardiac function and sleep respiratory events

Summary

There is an increased awareness of obesity in early years of life and its effect on cardio-metabolic risk factors and health outcomes. An adverse cardio-metabolic risk profile in young individuals can lead to increasing rates of cardiovascular and respiratory morbidities at an earlier age. Type 2 diabetes and prediabetic conditions such as insulin resistance and metabolic syndrome are closely associated with obesity and can significantly affect both the cardiovascular and respiratory systems. Cardiovascular autonomic neuropathy and obstructive sleep respiratory events can have life threating consequences. Both conditions can affect the quality of life of the affected individuals. Previously, these conditions were considered limited to middle-aged individuals and the elderly. However, recent studies have shown that they can also manifest in adolescents and young adults with metabolic risk factors. Most of the previous research has focused on middle-aged and elderly populations. This PhD, however, will examine the association between overweight and obesity, and cardio-metabolic risk factors with cardiac autonomic neuropathy and obstructive respiratory events in adolescents and young adults. In the first study, cardiac autonomic neuropathy and its association with cardio-metabolic risk factors will be evaluated in obese adolescents with and without Type 2 diabetes. The second study will examine obstructive respiratory events and sleep pattern in young adults and associations with insulin resistance, metabolic syndrome and other cardio-metabolic risk factors.

Why my research is important

This study evaluates the effects of cardio-metabolic risk factors on heart rate variability and sleep patterns in adolescents and young adults. These age groups have infrequently been studied before.The association between metabolic syndrome, insulin resistance and sleep-respiratory patterns in young adults will be evaluated longitudinally using data from The Western Australian Pregnancy Cohort (Raine) Study for the first time.