The Fremantle Diabetes Study (FDS) was a longitudinal observational study of community-based people with diabetes from an urban postcode-defined population base of 120,097 in Fremantle, Western Australia.
The study was led by Professor Timothy Davis at UWA.
Of 2,258 people identified with diabetes between April 1993 and July 1996, 1,426 were recruited to the study and 1,294 of these had type 2 diabetes.
At baseline, comprehensive physical, biochemical and socio-demographic data were collected from participants. Outcome data was obtained from the WA Hospital Morbidity Database and the State Death Register from January 1993 to June 2006. Cardiovascular disease (CVD) during follow-up was defined as hospitalisation for/with myocardial infarction or stroke, death from cardiac or cerebrovascular causes, or sudden death.
The FDS CVD risk calculator for type 2 diabetes is a presentation of the FDS model for 5-year risk of a major CVD event. The model estimates the probability of a major CVD event occurring in a given patient during the next 5 years, dependent on the patient’s risk factors.
The paper describing the development of the 5-year CVD risk calculator for type 2 diabetes was published in 2009:
W A Davis, M W Knuiman, T M E Davis. An Australian cardiovascular risk equation for type 2 diabetes: The Fremantle Diabetes Study. Internal Medicine Journal, “accepted article”; doi 10.1111/j.1445-5994.2009.01958x
The inputs to the model comprise:
The model is for use in usual-care patients with type 2 diabetes who should already be subject to proven interventions such as statin and aspirin therapy, smoking cessation, together with measures to increase HDL-cholesterol and ensure tight blood pressure control with consideration of use of agents that block the renin-angiotensin system, regardless of antihypertensive effect.
The study defined:
Although the model was developed in patients with a broad range of age (14.8 to 96.9 years) and other input variables, the results for people at the extremes of age, HDL-cholesterol, urinary ACR and HbA1c should be viewed with caution.
The generalisability of the model to populations with type 2 diabetes outside WA is not yet known.
You are eligible to participate if:
Phase II: National Health and Medical Research Council Project Study Protocol (download Phase II Study Protocol)
Fremantle Diabetes Study Phase II, Information Sheet invites you to participate in an observational study of diabetes in
people living in the primary catchment area of Fremantle Hospital. (download Infosheet_adult.pdf)